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Bromelain quick review
Description: a mixture of sulfur-containing protein-digesting enzymes, mainly comprised of cysteine proteases, with smaller amounts of acid phosphatase, peroxidase, amylase and cellulase.
Health benefits: reduces reduces swelling, bruising, redness, and tenderness following surgery and physical injuries; enhances the effect of such digestive enzymes as trypsin or pepsin; fights against infectious agents such as viruses and bacteria.
 
Bromelain 400mg by Vitabase
The main health areas in which bromelain has proven to be effective are as an anti-inflammatory, in reducing the time needed for wound healing, and as an aid to digestion. Apart from wound healing, the anti-inflammatory action of bromelain is also useful for reducing the pain and joint stiffness of chronic arthritis, easing the pain and swelling associated with gout, and helping sufferers of carpal tunnel syndrome. Click here for more information.
 

Bromelain


Bromelain is an enzyme found in pineapples that breaks down other proteins, such as collagen and muscle fiber. Bromelain is not a single substance, but rather a collection of enzymes and other compounds. It is a mixture of sulfur-containing protein-digesting enzymes, called proteolytic enzymes or proteases. It also contains several other substances in smaller quantities, including perioxidase, acid phosphatase, protease inhibitors, and calcium. Bromelain is one of a group of proteolytic enzymes (enzymes capable of digesting protein). Proteolytic enzymes (proteases and peptidases are also commonly used) are enzymes which break peptide bonds of proteins. In the body, proteolytic digestive enzymes are produced in the pancreas, but supplemental forms of enzymes may come from fungal or bacterial sources, extraction from the pancreas of livestock animals (trypsin/chymotrypsin) or extraction from plants. The primary uses of proteolytic enzymes in dietary supplements are as digestive enzymes, anti-inflammatory agents and pain relievers. Bromelain is mainly comprised of cysteine proteases, with smaller amounts of acid phosphatase, peroxidase, amylase and cellulase. Like all enzymes (papain and other proteases), bromelain breaks down the connecting structure that holds surface skin cells together. The process is called proteolytic cleavage. They use a molecule of water for this and are thus classified as hydrolases.

 

Health benefits of bromelain


Bromelain is useful in the treatment of a wide range of conditions. Bromelain is a natural blood thinner and anti-inflammatory. Bromelain supplements may reduce reduces swelling, bruising, redness, and tenderness following surgery and physical injuries. Bromelain (applied to the surface of the skin) may be useful in removing dead tissue from third-degree burns. Bromelain breaks down fibrin, a blood-clotting protein that can impede good circulation and prevent tissues from draining properly. Bromelain's anti-clotting activity may be useful in preventing strokes. Bromelain can enhance the effect of such digestive enzymes as trypsin or pepsin. The protein-digesting enzymes found in bromelain help promote and maintain proper digestion and may relieve symptoms of stomach upset or heartburn. Bromelain can fight against infectious agents such as viruses and bacteria, in combination with trypsin bromelain may enhance the effect of antibiotics in people with a urinary tract infection (UTI). Bromelain has also been proposed in the use of arthritis, chronic venous insufficiency, easy bruising, gout, hemorrhoids, menstrual pain, autoimmune disorders, and ulcerative colitis. Studies have shown that bromelain can also be useful in the reduction of platelet clumping and blood clots in the bloodstream, especially in the arteries.
 

Dosage and administration


Bromelain is available as a single ingredient product or in combination with other supplementary enzymes in tablet or capsule form for oral use. It may also be used topically to treat severe burns. The German Commission E recommends 80 to 320 mg two to three times per day for adults. Symptoms of angina pectoris may relieved with dosage of bromelain to 400-1,000 mg per dayFor anti-inflammatory benefits, use between meals, 1-3 tablets (250-500mg) up to 4 times a day. However, bromelain's activity is measured in GDUs (gelatin digesting units) or MCUs (milk clotting units). One GDU (Gelatin Dissolving Unit) is equivalent to 1.5 MCU (Milk Clotting Units). Normally dosage ranges from 500-2,000 GDUs taken one to three times daily.
 

Side effects, precautions, and interactions


Bromelain is generally considered safe at recommended doses. Possible side effects from bromelain include nausea, vomiting, diarrhea, and excessive menstrual bleeding. Because of bromelain's anti-clotting activity, it should be cautious when combining bromelain with anticoagulants (blood thinners), such as enoxaparin or warfarin. Those individuals at risk for gastric or duodenal ulcers should avoid bromelain. Bromelain is generally recommended for no longer than 8 to 10 days in a row.